Table 3 Top 10 differentially expressed genes between ICSI BCB+ and ICSI BCB−; mICSI BCB− and ICSI BCB−; and mICSI BCB− and ICSI BCB+ blastocysts following unpaired t-tests, with FC > 2 (abs) and significance of p < 0.01.
Top 10 differentially expressed genes (T-Test, p value < 0.01, abs. FC > 2) | FC (abs) | p value | Regulation | REFSEQ | Network | Top Diseases and Functions |
|---|---|---|---|---|---|---|
ICSI BCB − vs ICSI BCB + blastocysts | ||||||
LOC100513964 | 109.53825 | 0.000014519855 | up | XM_003134882 | Not displayed | Undetermined |
BNP | 45.177853 | 0.005953322 | up | NM_213846 | Not displayed | Undetermined |
NULL | 34.279636 | 0.0000691877 | up | unknown | Not displayed | Undetermined |
ROCK2 | 29.54274 | 0.0013772815 | up | XM_003125386 | Cell Morphology, Cellular Assembly and Organization, Cellular Function and Maintenance | |
LOC100518872 | 25.287235 | 0.0013035844 | up | XM_003133613 | Not displayed | Undetermined |
NULL | 77.53339 | 0.008828815 | down | unknown | Not displayed | Undetermined |
ZNF709 | 33.383026 | 0.0010354982 | down | XM_003354054 | Not displayed | Cellular Growth and Proliferation, Cell Death and Survival, Infectious Disease |
LOC100520571 | 21.369652 | 0.0006056553 | down | XM_003128006 | Not displayed | Undetermined |
ACTG2 | 19.070107 | 0.00027356512 | down | NM_001615.3 | Not displayed | Inflammatory Disease, Inflammatory Response, Organismal Injury and Abnormalities |
TC2N | 13.784387 | 0.008354094 | down | NM_028924.3 | Amino Acid Metabolism, Post-Translational Modification, Small Molecule Biochemistry | |
mICSI BCB − vs ICSI BCB − blastocysts | ||||||
SERPINB10 | 50.39668 | 0.0082500875 | up | NM_005024.1 | Cellular Development, Cellular Growth and Proliferation, Hematological System Development and Function | |
NULL | 28.870111 | 0.008353462 | up | unknown | Not displayed | Undetermined |
ADAM5 | 19.022522 | 0.0037702504 | up | XM_003133371 | Not displayed | Undetermined |
NULL | 16.16526 | 0.002920586 | up | unknown | Not displayed | Undetermined |
LOC100625749 | 14.306636 | 0.005585119 | up | XM_003361441 | Not displayed | Undetermined |
LOC100513964 | 98.986435 | 0.000018220118 | down | XM_003134882 | Not displayed | Undetermined |
NULL | 50.691635 | 0.000014981616 | down | unknown | Not displayed | Undetermined |
IL18 | 37.155396 | 0.00052243227 | down | NM_001243211 | Cell-To-Cell Signaling and Interaction, Cell Signaling, Molecular Transport | |
LOC100623696 | 36.893543 | 0.008665602 | down | XM_003356823.1 | Not displayed | Undetermined |
MATN3 | 35.507694 | 0.00008970674 | down | NM_002381 | Cell Morphology, Cellular Assembly and Organization, Cellular Development | |
mICSI BCB − vs ICSI BCB + blastocysts | ||||||
PPP1R9A | 57.586193 | 0.00099 | up | NM_001166160 | Not displayed | Cellular Compromise, Infectious Disease, Drug Metabolism |
NULL | 56.806114 | 0.003806175 | up | unknown | Not displayed | Undetermined |
LOC100623901 | 44.763016 | 0.000384 | up | XM_003361640 | Not displayed | Undetermined |
LOC100526251 | 38.66665 | 0.0000941 | up | XM_003132878.1 | Not displayed | Undetermined |
LIX1L | 35.739998 | 0.000215 | up | NM_153713 | Not displayed | Undetermined |
LOC100524253 | 56.918842 | 0.007135105 | down | XM_003355205 | Not displayed | Undetermined |
LOC100628218 | 41.88254 | 0.002997461 | down | XM_003354336.1 | Not displayed | Undetermined |
ZC3HAV1 | 40.911594 | 0.001792942 | down | NM_024625 | Not displayed | Cellular Compromise, Infectious Disease, Drug Metabolism |
NULL | 31.49758 | 0.005764906 | down | unknown | Not displayed | Undetermined |
NR3C1 | 21.502375 | 0.007265344 | down | NM_001008481.1 | Not displayed | Cellular Compromise, Infectious Disease, Drug Metabolism |
