Table 2 Surgical and pathological details.

From: Surgical Outcomes of Synchronous Multiple Primary Non-Small Cell Lung Cancers

Variables

Total (n = 285)

Staging operation, n (%)

 Single-stagea

192 (67.4)

 Two-stage

93 (32.6)

Laterality, n (%)

 Unilateral

191 (67.0)

 Bilateral

94 (33.0)

Approach, n (%)

 Unilateral

  Thoracotomy

107 (37.5)

  VATS

84 (29.5)

 Bilateral

  Thoracotomy+Thoracotomy

27 (9.5)

  VATS+VATSa

49 (17.2)

  VATS+Thoracotomy

18 (6.3)

Type of surgical resection, n (%)

 Multi-lobectomy

87 (30.5)

 Lobectomy+sublobar resectionsb

139 (48.8)

 Sublobar resections

59 (20.7)

Location of lobe, n (%)

 Same lobe

55 (19.3)

 Different lobe

190 (66.7)

 Combined lobec

40 (14.0)

No. of tumor, n (%)

 2

234 (82.1)

 3

33 (11.6)

 ≥4

18 (6.3)

Largest T size, cm, n (%)

 ≤2

103 (36.2)

 2 < d ≤ 3

93 (32.6)

 3 < d ≤ 5

72 (25.3)

 d > 5

17 (5.9)

Histology type, n (%)

 ADCs (multiple)

233 (81.8)

 SCCs (multiple)

27 (9.5)

 ADC+otherd

9 (3.1)

 SCC+othere

2 (0.7)

 ADC+SCC

14 (4.9)

Subtypes of largest tumorf, n (%)

 Lepidic predominant

69 (29.6)

 Acinar predominant

122 (52.3)

 Papillary predominant

23 (9.9)

 Micropapillary predominant

6 (2.6)

 Solid predominant

13 (5.6)

Highest pT stageg, n (%)

 1a

11 (3.8)

 1b

45 (15.8)

 1c

19 (6.7)

 2ah

175 (61.4)

 2b

15 (5.3)

 3

16 (5.6)

 4

4 (1.4)

pN stage, n (%)

 0

217 (76.1)

 1

27 (9.5)

 2

41 (14.4)

Adjuvant chemotherapyi, n (%)

 Yes

119 (41.8)

 No

166 (58.2)

  1. Abbreviations: VATS, video-assisted thoracic surgery. ADC, adenocarcinoma. SCC, squamous cell carcinoma.
  2. aOne was single-stage treatment of bilateral Cancers via VATS.
  3. bSegmentectomy and wedge resection.
  4. cMore than 2 cancers, at least 2 tumors were located at the same lobe and the other or others located at the different.
  5. dAdenosquamous carcinoma, carcinoid, sarcomatoid carcinoma and large cell carcinoma.
  6. ePleomorphic carcinoma and carcinoid.
  7. fMultiple adenocarcinomas (n = 233).
  8. gThe new revision of T stage in the forthcoming 8th TNM system.
  9. hIncluding a tumor with a diameter ≤3 cm but invades visceral pleura.
  10. iPemetrexed, gemcitabine, or paclitaxel combined with platinum.