Figure 1: Enhanced multi-drug resistance induced by various stimuli.
From: Regulation of Multi-drug Resistance in hepatocellular carcinoma cells is TRPC6/Calcium Dependent
Stimuli with doxorubicin (Pre-Dox) (red), hypoxia (orange) and ionizing radiation (Pre-IR) (blue) all significantly (p < 0.05, stimuli group vs. normality group) increased the relative cell viability (Mean ± SD) (n = 6) of Huh7 and HepG2 cells, treated by various concentrations of (a) doxorubicin, (b) 5-fluorouracil or (c) cisplatin. Best-fit lines are presented. Statistical significances were assessed using one-way ANOVA with Bonferroni’s post-tests.
