Figure 3
From: Regulation of Multi-drug Resistance in hepatocellular carcinoma cells is TRPC6/Calcium Dependent
Calcium chelation (a) fails (p > 0.05) to affecte the drug sensitivity of unstimulated cells (normality) to doxorubicin but significantly (p < 0.05) attenuates the enhancement of HCC cells’ resistance to doxorubicin by stimuli with (b) doxorubicin (Pre-Dox), (c) hypoxia and (d) ionizing radiation (Pre-IR). Relative cell viability (Mean ± SD) (n = 6) was calculated for control (black) and calcium chelation (orange) groups and best-fit lines are presented. Statistical significances were assessed using one-way ANOVA with Bonferroni’s post-tests.
