Figure 6 | Scientific Reports

Figure 6

From: P2X7 Receptor Suppression Preserves Blood-Brain Barrier through Inhibiting RhoA Activation after Experimental Intracerebral Hemorrhage in Rats

Figure 6

Effects of P2X7 receptor modulation on the expressions of endothelial junction proteins at 24 hours after ICH.

(A) Representative bands and quantitative analysis of the expressions of Occudin, VE-Cadherin and zonula occluden-1 (ZO-1) after A438079 treatment with/without BzATP pretreatment at 24 hours post-ICH in each group. (B) Representative bands and quantitative analysis of the expressions of Occudin, VE-Cadherin and zonula occluden-1 (ZO-1) with P2X7 siRNA pretreatment at 24 hours after ICH in each group. Relative densities of each protein have been normalized against the sham group. The cropped bands had been run under the same experimental conditions. *p < 0.05 vs Sham; #p < 0.05 vs Vehicle; &p < 0.05 vs A438079; @p < 0.05 vs Scramble siRNA. n = 4 per group.

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