Figure 1

Schematic illustration of the general idea of this study.

CT scan is first performed on the tumorous bone (A). The CT scan image is then used to reconstruct a 3D model of the tumorous bone using Simpleware software (B). The 3D model is then used to design a guiding template using reverse engineering software (C). The model of the guiding template is then used to fabricate the template by 3D printing (D). The 3D printed template is characterized by SEM imaging (E) and biomechanical testing (F). The template is further used to guide the surgery of osteosarcoma (G). The patient is followed after surgery to test the efficacy of the surgery (H).