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Figure 1

From: Genome-wide Long Non-coding RNA Analysis Identified Circulating LncRNAs as Novel Non-invasive Diagnostic Biomarkers for Gynecological Disease

Figure 1

Abnormal expression of lncRNAs in serum and tissue from endometriosis and control patients.

(A) Scatter plot of circulating lncRNA expression between the endometriosis and control samples; green spots show a difference >2. (B) Scatter plot of expression of lncRNAs between ectopic endometrium and eutopic endometrium; red spots show a difference >2. (C) Set diagram showing dysregulated lncRNA expression between the serum and tissue samples; (D) The deregulated lncRNAs were classified into different sets: retained introns (4%), lincRNAs (12%), or antisense RNAs (82%);(E) Cluster analysis of lncRNA expression in endometriosis patient serum and serum controls, eutopic endometrium tissue samples, ectopic endometrium tissue samples and negative tissue controls. The 65 top-ranked, differentially expressed lncRNAs are displayed (fold-change > 2.0). The expression values are represented in red and green, indicating expression above and below the median expression value across all samples, respectively. Each pooled sample has an array of data in the heatmap.

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