Figure 2 | Scientific Reports

Figure 2

From: Genome-wide Long Non-coding RNA Analysis Identified Circulating LncRNAs as Novel Non-invasive Diagnostic Biomarkers for Gynecological Disease

Figure 2

Circulating lncRNAs differentially expressed in patients with or without endometriosis.

The expression levels of lncRNAs in serum samples from patients with endometriosis (n = 59) and control patients (n = 51) were detected with an absolute quantitative RT-PCR assay and box plots illustrate the distinction. The copy numbers of NR_038452 (A) and ENST00000393610 (B) were higher in endometriosis patients than in the controls (P < 0.01), while the copy number of ENST00000465368 (C) P < 0.05), NR_033688 (D) P < 0.01), ENST00000482343 (E) P < 0.001), NR_038395 (F) P < 0.05), ENST00000544649 (G) P < 0.01) and ENST00000529000 (H) P < 0.05) were lower in endometriosis patientsthan in the controls. All P values were determined with a two-tailed Mann-Whitney U test. Additionally, altered expression levels of ENST00000482343 (I), NR_033688 (J), NR_038452 (K) and NR_038395 (M) were observed in patients with varying levels of endometriosis severity. Notably, the expression level of ENST00000482343 continued to decrease as the disease progressed (P < 0.05). A Kruskal-Wallis test was implemented among the 3 groups,and multiple comparisons were carried out using a LSD-t test. *, **, *** represents P < 0.05, P < 0.01 and P < 0.001, respectively.

Back to article page