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Figure 2

From: Deletion of Galectin-3 Enhances Xenobiotic Induced Murine Primary Biliary Cholangitis by Facilitating Apoptosis of BECs and Release of Autoantigens

Figure 2

Deletion of Gal-3 enhanced PBC in C57BL/6 mice.

(A) Number of mice with parameters of liver inflammation, granuloma formation and fibrosis. (B) Total score I (liver infiltration and bile duct damage) and score II (liver fibrosis and granuloma formation). (C) Total number of mononuclear cells. (D) Representative liver sections of immunized WT (a–c) and Gal-3 KO (d–f); non-immuniezed WT (g,h) and Gal-3 KO (i,j) mice, arrows indicate: periductal mononuclear cell infiltrate (black); parenchymal infiltration (red); granuloma formation (violet); bile duct damage (yellow); bile duct obliteration (blue); no infiltration in control mice (green). (E) Serum levels of anti-PDC-E2 antibodies in non-immunized mice (week 0) and 4, 6 and 8 weeks after immunization with xenobiotic. (F) AST/ALT ratio in serum. Data presented as mean + SE, 9 mice per group, *p < 0.05, **p < 0.005.

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