Figure 6 | Scientific Reports

Figure 6

From: Deletion of Galectin-3 Enhances Xenobiotic Induced Murine Primary Biliary Cholangitis by Facilitating Apoptosis of BECs and Release of Autoantigens

Figure 6

Gal-3 deletion increases serum levels of profibrotic IL-13 and IL-17 cytokines and fibrosis in 2OA-BSA induced PBC.

(A) Serum levels of IL-13, IL-6, IL-17 and IFN-γ and (B) liver immunohistochemistry of CK-7 in WT and Gal-3 KO mice eight weeks after immunization with 2OA-BSA. (C) Liver fibrosis score of WT and Gal-3 KO mice and representative liver sections stained with Sirius red indicating minimal fibrosis in WT mice (black arrows) and marked fibrosis in Gal-3 KO mice (red arrows). Data are presented as the mean + SE; 9 mice per group, *p < 0.05.

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