Table 1 Kinetic and thermodynamic parameters of Aβ40 amyloid aggregation.

From: Ultra rapid in vivo screening for anti-Alzheimer anti-amyloid drugs

Inhibitor

Without

DP-128 a

Apigenin a

kn (106·min−1)

200.5

118.5

135.0

keapp (M−1·min−1)b,c

2723.5

4427.8

5336.5

[Aβ40fibrils]·ke (min−1)

0.0164

0.0179

0.0173

t0 (min)

112.0

140.6

144.3

t1/2 (min)

268.3

279.4

279.4

t1 (min)

424.5

418.3

414.6

[Aβ40fibrils] (μM)d

6.0

4.0

3.2

  1. aInhibition parameters at 10 μM of inhibitor.
  2. bSince Aβ40 concentration is not constant along the aggregation process, the ke are apparent.
  3. cIn order to calculate the keapp, the final Aβ40 amyloid amount of each aggregation kinetic has been considered.
  4. dAβ40 concentration in amyloid conformation at end-point of the time-course.
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