Figure 2: Schematic diagrams of the predicted structures of the MDR49 proteins, encompassing the T374I, M388L, and E666D for MDR49A; T173I, M187L, and E465D for MDR49B amino acid replacement sites.
From: Splice form variant and amino acid changes in MDR49 confers DDT resistance in transgenic Drosophila
(A) Twelve transmembrane segments in two transmembrane domains (TMD 1 and TMD 2) were predicted in the MDR49A isoform. (B) Nine transmembrane segments were predicted in two TMDs in the MDR49B isoform. Amino acid replacements that may result in structural alterations are indicated by red dots. Blue letters represent 91-C; red letters represent 91-R.
