Figure 10: Histopathology (HE) and immunohistochemistry (IHC) findings in lungs from H5N1 infected mice. | Scientific Reports

Figure 10: Histopathology (HE) and immunohistochemistry (IHC) findings in lungs from H5N1 infected mice.

From: Pathobiological Characterization of a Novel Reassortant Highly Pathogenic H5N1 Virus Isolated in British Columbia, Canada, 2015

Figure 10

(A) Day 3: Mild to moderate bronchiolitis (arrow) and scattered foci of interstitial pneumonia (*). HE, bar = 100 μm. (B) Day 6: Large areas of necrotizing interstitial pneumonia (*) and bronchiolitis (arrow). HE, bar = 100 μm. (C) Day 3: Positive immunostaining for influenza A antigen is primarily observed in bronchiolar epithelial cells (arrow). IHC, bar = 50 μm. (D) Day 6: Viral antigen is detected in bronchiolar epithelial cells (arrows) as well as in macrophages (arrowheads). IHC, bar = 50 μm.

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