Figure 12: Neuraminidase enzyme kinetics and sensitivity of H5N1 viruses to oseltamivir. | Scientific Reports

Figure 12: Neuraminidase enzyme kinetics and sensitivity of H5N1 viruses to oseltamivir.

From: Pathobiological Characterization of a Novel Reassortant Highly Pathogenic H5N1 Virus Isolated in British Columbia, Canada, 2015

Figure 12

(A) Neuraminidase kinetic curves for FAV-002/H5N1 and AGT/H5N1. Relative fluorescent unit (RFU) values for each virus (FAV-002/H5N1 and AGT/H5N1) were plotted against a 2-fold dilution series of MUNANA to determine the maximum velocity (Vmax) and the binding affinity (Km) to MUNANA for each virus. (B) Comparative sensitivity to oseltamivir for each virus is reflected by the percent inhibition of enzyme activity at each concentration of oseltamivir carboxylate, plotted as the ratio of RFU at each dose over the RFU value with no drug treatment. P value < 0.0001.

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