Figure 9: Survival and weight loss of mice infected with H5N1 and H5N8 viruses.

Six- to 7-week-old female Balb/c mice were intranasally challenged with 10 fold serial dilutions of FAV-002/H5N1 (A,D), AGT/H5N1 (B,E) and AW-050/H5N8 (C,F) and observed for survival and weight loss. The percent survival was determined and mouse 50% lethal dose (MLD50) was calculated by the Miller and Tainter method (43). N = 6 mice per group.