Figure 1
From: Biological insertion of computationally designed short transmembrane segments
Predicted membrane insertion efficiencies for computationally designed sequences.
(A) Probability of insertion (pi) for a series of computationally designed TM segments of different lengths. First row corresponds to the predictions of pi values for polyleucine stretches of different lengths (l). Each row in descending order represents the inclusion of a specific amino acid to the TM segment composition used in the previous row. The row order is derived from the prevalence for each amino acid type in TM helix composition in a previous structure-based statistical analysis7. (B) Similar to (A) but including in the computational design information of the position-dependent distribution for each amino acid type in TM helices7. (C) Differences between the position-defined (B) pi values and those obtained for the computed sequences using only amino acid composition constraints (A).
