Table 1 Allelic and genotypic frequencies of the polymorphisms of the NOS3 gene in individuals with thalidomide embryopathy, as well as in Brazilian individuals without congenital anomalies (unaffected group).

From: New Findings in eNOS gene and Thalidomide Embryopathy Suggest pre-transcriptional effect variants as susceptibility factors

Gene

Polymorphism

Genotype/Allele

Affected

Unaffected

P-Valuea

N

%

N

%

NOS3

rs2070744

CC

10

26.3

17

12.5

0.060

 

(C/T)

CT

17

44.7

57

41.9

 
  

TT

11

28.9

62

45.6

 
  

C

37

48.7

91

33.5

0.022

  

T

39

51.3

181

66.5

 
 

rs61722009

4b4b

27

71.1

81

61.8

0.263

 

(VNTR)

4b4a

11

28.9

41

31.3

 
  

4a4a

0

0.0

9

6.9

 
  

4b

59

85.5

203

77.5

0.149

  

4a

11

14.5

59

22.5

 
 

rs1799983

TT

5

13.2

13

9.6

0.360

 

(T/G)

TG

21

55.3

63

46.7

 
  

GG

12

31.6

59

43.7

 
  

T

31

40.8

89

33.0

0.221

  

G

45

59.2

181

67.0

 
  1. aChi-Square Test.
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