Table 1 Half-maximal inhibitory concentration (IC50) (μM, mean ± SD, n = 3) values of free PTX, PCVPTX and fP-PCVPTX against SKOV-3 and A549 cell lines.
From: Paclitaxel-loaded phosphonated calixarene nanovesicles as a modular drug delivery platform
Short Incubation Regime (4 h pulsed exposure) | Long Incubation Regime (72 h continuous exposure) | |||||||
|---|---|---|---|---|---|---|---|---|
Cell lines | Free PXT | PCVPTX | fP-PCVPTX | fP-PCVPTX with free folate | Free PXT | PCVPTX | fP-PCVPTX | fP-PCVPTX with free folate |
SKOV-3 | 3.79 ± 0.31 | 8.68 ± 0.88 | 2.42 ± 0.29 | 5.87 ± 0.56 | 0.30 ± 0.03 | 0.94 ± 0.11 | 0.43 ± 0.04 | 0.62 ± 0.05 |
A549 | 2.25 ± 0.19 | 8.73 ± 0.91 | 7.88 ± 0.82 | 6.42 ± 0.55 | 0.16 ± 0.02 | 0.49 ± 0.04 | 0.40 ± 0.05 | 0.47 ± 0.04 |
