Figure 1: Differential expression profile of lncRNAs in HBx transfected LO2 cells. | Scientific Reports

Figure 1: Differential expression profile of lncRNAs in HBx transfected LO2 cells.

From: HBx-upregulated lncRNA UCA1 promotes cell growth and tumorigenesis by recruiting EZH2 and repressing p27Kip1/CDK2 signaling

Figure 1

(a) Hierarchical clustering analysis of lncRNAs. 379 up-regulated lncRNAs (fold change ≥2, P < 0.05) and 97 down-regulated lncRNAs (fold change ≥4, P < 0.05) were differentially expressed in HBx-expressing cells. The upregulated lncRNAs are represented in red, and the downregulated lncRNAs are displayed in green. The experiments were conducted in three biological replicates. (b) The fold change of lncRNA in microarray. (c) Nine differentially expressed lncRNAs randomly selected from panel (a) were validated by real-time PCR. Two LO2-HBx stable cell lines (LO2-HBx #1 and LO2-HBx #8) and LO2-HBx mixed stable cells were used to validate lncRNA profiles. Statistically significant differences are reported (Student t-test) for three independent experiments. *P < 0.05.

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