Figure 6 | Scientific Reports

Figure 6

From: Prohibitin-induced, obesity-associated insulin resistance and accompanying low-grade inflammation causes NASH and HCC

Figure 6

Schematic diagram showing proposed mechanism in obesity-linked NASH and HCC development.

We propose that an extensive interplay between the metabolic and inflammatory status at the adipose tissue and systemic levels, as well as at the hepatic tissue level is involved in the progression of obesity-linked hepatic steatosis to NASH and HCC. Pro – proinflammatory; Anti – anti-inflammatory.

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