Table 1 Profile of the euthanasia criteria met for NHP exposed to 9.0–12.5 Gy PBI/BM5 before the end of study at 180 days post-irradiation.
From: A non-human primate model of radiation-induced cachexia
Radiation Doses (Gy) | Total # of NHP | Number (%) of NHP euthanized before end of study | Number (%) of NHP euthanized before end of study for criteria | ||||
|---|---|---|---|---|---|---|---|
25% BW loss >72h | 20% BW loss >72h combination | Inactivity | Respiratory distress or SpO2 < 88% | Others | |||
9.0 | 6 | 1 (16.7) | 0 | 1 (16.7) | 0 | 0 | 0 |
10.0 | 30 | 15 (50.0) | 5 (16.7) | 0 | 4 (13.3) | 5 (16.7) | 1 (6.7) |
11.0 | 43 | 37 (86.0) | 8 (18.6) | 2 (4.6) | 6 (14.0) | 11 (25.6) | 10 (23.3) |
11.5 | 12 | 12 (100) | 4 (33.3) | 1 (8.3) | 2 (16.7) | 3 (25.0) | 3 (25.0) |
12.0 | 17 | 17 (100) | 3 (17.6) | 2 (11.8) | 8 (47.1) | 0 | 4 (23.5) |
12.5 | 4 | 4 (100) | 0 | 0 | 2 (50.0) | 1 (25.0) | 1 (25.0) |
All doses | 112 | 86 (76.8) | 20 (17.9) | 6 (5.4) | 22 (19.6) | 20 (17.9) | 19 (17.0) |
