Figure 1: The Val66Met polymorphism of the BDNF is associated with the menstrual cycle variation in the functional expression of the descending pain modulatory system. | Scientific Reports

Figure 1: The Val66Met polymorphism of the BDNF is associated with the menstrual cycle variation in the functional expression of the descending pain modulatory system.

From: The BDNF Val66Met polymorphism is associated with the functional connectivity dynamics of pain modulatory systems in primary dysmenorrhea

Figure 1

Regions exhibit significant (FWE-corrected voxel level p < 0.05) resting-state functional connectivity with the PAG for between-group and/or between-genotype comparisons. Each region’s detail is listed in Tables 3 and 4 and Supplementary Table S3. The results are superimposed on the SPM T1 template, and the color bar represents t-scores. All figures adopt neurological orientation (left = left). The bar charts show the adjusted functional connectivity at the peak voxel of each region (coordinates in Montreal Neurological Institute space) for each genotype (V, valine; M, methionine) across the two groups (PDM, primary dysmenorrhea; CON, control) during the two phases (MENS, menstrual; POV, periovulatory). The error bar corresponds to a 90% confidence interval. *denote the contrasts that are significant in the between-group comparisons of each genotype (red) or between-genotype comparisons of each group (blue).

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