Table 1 Top five enriched canonical pathways in the proteomic comparison of FTC/N and PTC/N.

From: Proteomics of thyroid tumours provides new insights into their molecular composition and changes associated with malignancy

Name

p-value

Overlap

Molecules

FTC/N

 Acute phase response signaling

2.19E-07

4.8%

A2M,APCS,C4BPA,FGA,FGB,FGG,HP,RRAS

 LXR/RXR Activation

6.24E-06

5.0%

APOB,APOC3,CLU,FGA,LYZ,S100A8

 Coagulation system

8.81E-06

11.4%

A2M,FGA,FGB,FGG

 Extrinsic prothrombin activation pathway

2.76E-05

18.8%

FGA,FGB,FGG

 Atherosclerosis signaling

9.25E-05

4.1%

APOB,APOC3,CLU,LYZ,S100A8

PTC/N

 Actin Cytoskeleton Signaling

2.09E-11

8.1%

ACTB,ACTG1,ACTR2,ARPC1B,ARPC3,ARPC4,ARPC5,FN1,GNG12,GSN,MSN,MYH11,MYL4,PFN1,RAC2, TMSB10/TMSB4X,WASF2

 Remodeling of epithelial adherens junction

7.00E-10

15.2%

ACTB,ACTG1,ACTR2,ARPC1B,ARPC3,ARPC4,ARPC5,CDH1,TUBA4A,ZYX

 Regulation of actin-based motility by Rho

1.12E-08

11.5%

ACTB,ACTR2,ARPC1B,ARPC3,ARPC4,ARPC5,GSN,MYL4,PFN1,RAC2

 RhoGDI signaling

1.20E-08

7.6%

ACTB,ACTG1,ACTR2,ARHGDIB, ARPC1B,ARPC3,ARPC4,ARPC5,CDH1,GNG12,MSN,MYL4,WASF2

 Epithelial Adherens Junction Signaling

1.38E-08

8.4%

ACTB,ACTG1,ACTR2,ARPC1B,ARPC3,ARPC4,ARPC5,CDH1,MYH11,MYL4, TUBA4A,ZYX

  1. The overlap represents the number of differentially expressed proteins divided by the total number of molecules in the canonical pathway.
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