Table 2 Genome-wide significant plasma ApoH GWAS results for the discovery meta-analysis and the replication sample for Model 2 (age, sex, assay batch, hypolipidemic medication).
SNP (rs) | Chr | BP | Effect Allele (minor) | Beta (S.E.) | Discovery p-value | Direction | Variance Explained | Replication p-value (HCS) | Direction (HCS) | Gene | Feature |
|---|---|---|---|---|---|---|---|---|---|---|---|
rs7211380 | 17 | 64206768 | G | −1.20 (0.19) | 8.15E-11 | − − | 0.037 | 0.000517 | − | APOH | 3′ |
rs11651658 | 17 | 64198640 | C | −1.19 (0.18) | 1.02E-10 | − − | 0.036 | 0.000872 | − | NA | Near APOH |
rs1014399 | 17 | 64196331 | A | −1.16 (0.18) | 2.20E-10 | − − | 0.035 | 0.001453 | − | NA | Near APOH |
rs8178853 | 17 | 64215058 | A | −1.12 (0.19) | 3.82E-09 | − − | 0.030 | 0.001138 | − | APOH | intron |
rs8178851 | 17 | 64215239 | C | −1.12 (0.19) | 3.85E-09 | − − | 0.030 | 0.001141 | − | APOH | intron |
rs8178841 | 17 | 64219197 | A | −1.12 (0.19) | 3.86E-09 | − − | 0.030 | 0.001157 | − | APOH | intron |
rs8178838 | 17 | 64219541 | C | −1.12 (0.19) | 3.92E-09 | − − | 0.030 | 0.001139 | − | APOH | intron |
rs16958979 | 17 | 64223859 | T | −1.12 (0.19) | 4.01E-09 | − − | 0.030 | 0.001116 | − | APOH | intron |
rs7213041 | 17 | 64224616 | T | −1.12 (0.19) | 4.01E-09 | − − | 0.030 | 0.001112 | − | APOH | intron |
rs8178847 | 17 | 64216815 | T | −1.12 (0.19) | 4.26E-09 | − − | 0.030 | 0.001157 | − | APOH | missense (Arg –> His) |
rs8178822 | 17 | 64225529 | T | −1.12 (0.19) | 4.27E-09 | − − | 0.030 | 0.001122 | − | APOH | UTR 5′ |
rs8178842 | 17 | 64218640 | T | −1.12 (0.19) | 4.29E-09 | − − | 0.030 | 0.001157 | − | APOH | Intron |
