Table 3 Suggestive plasma ApoH GWAS results for the discovery meta-analysis and the replication sample for Model 2 (age, sex, assay batch effects, hypolipidemic medication).
SNP (rs) | Chr | BP | Effect Allele | Beta (S.E.) | Discovery p-value | Direction | Variance explained | Replication p-value (HCS) | Direction (HCS) | Gene | Feature |
|---|---|---|---|---|---|---|---|---|---|---|---|
rs2873966 | 17 | 64211973 | A | 0.53 (0.10) | 2.54E-07 | + + | 0.025 | 0.068927 | + | APOH | intronic |
rs11655503 | 17 | 64027346 | A | −0.97 (0.19) | 4.24E-07 | − − | 0.028 | 0.010205 | − | CEP112 | intronic |
rs8064837 | 17 | 64242703 | G | −0.46 (0.09) | 5.11E-07 | − − | 0.023 | 0.113782 | − | N/A | N/A |
rs1420791 | 17 | 63914750 | G | −0.92 (0.19) | 8.90E-07 | − − | 0.022 | 0.011073 | − | CEP112 | intronic |
rs2010251 | 17 | 64203725 | T | −0.61 (0.13) | 1.26E-06 | − − | 0.022 | 0.03413 | − | N/A | N/A |
rs758767 | 17 | 64204591 | A | −0.61 (0.13) | 1.26E-06 | − − | 0.022 | 0.034137 | − | N/A | N/A |
rs7214750 | 17 | 63903119 | T | −0.90 (0.19) | 1.30E-06 | − − | 0.021 | 0.015964 | − | CEP112 | intronic |
rs6431248 | 2 | 235202974 | A | 0.46 (0.10) | 3.00E-06 | + + | 0.021 | 0.722578 | + | N/A | N/A |
rs181247 | 17 | 56207731 | A | 0.58 (0.13) | 4.88E-06 | + + | 0.028 | 0.021183 | + | N/A | N/A |
rs12825437 | 12 | 5756980 | A | −0.65 (0.14) | 5.91E-06 | − − | 0.019 | 0.486807 | + | TMEM16B | intronic |
rs1519187 | 2 | 235201218 | T | 0.45 (0.10) | 7.18E-06 | + + | 0.02 | 0.876655 | + | N/A | N/A |
rs9562709 | 13 | 47727650 | A | 0.48 (0.11) | 8.83E-06 | + + | 0.018 | 0.488741 | − | N/A | N/A |
rs9591011 | 13 | 47728087 | T | 0.48 (0.11) | 9.04E-06 | + + | 0.017 | 0.488816 | − | N/A | N/A |
