Table 4 SNPs nominally to significantly associated with diabetes type 2 and cognitive domains in the Sydney Memory and Ageing Study (MAS) and replication results from the Older Australian Twins Study (OATS).
Trait | SNP | MAS | OATS | ||||||
|---|---|---|---|---|---|---|---|---|---|
Effect Allele | OR/Beta (S.E.) | p-value | N | Effect Allele | OR/Beta (S.E.) | Replication p-value (OATS) | N | ||
Diabetes Type 2 | rs2010251 | T | −1.668 (0.210) | 0.015 | 925 | T | 0.010 (0.029) | 0.730 | 512 |
Diabetes Type 2 | rs758767 | A | −1.668 (0.210) | 0.015 | 925 | A | 0.010 (0.029) | 0.730 | 512 |
Attention/Processing Speed | rs2010251 | T | −0.163 (0.073) | 0.026 | 909 | T | 0.072 (0.077) | 0.350 | 503 |
Attention/Processing Speed | rs758767 | A | −0.163 (0.073) | 0.026 | 909 | A | 0.072 (0.077 | 0.350 | 503 |
Attention/Processing Speed | rs2873966 | A | 0.194 (0.056) | 0.001 | 909 | A | −0.141 (0.073) | 0.054 | 503 |
Executive function | rs2873966 | A | 0.149 (0.061) | 0.014 | 851 | A | −0.081 (0.076) | 0.280 | 499 |
Global cognition | rs2873966 | A | 0.189 (0.057) | 0.001 | 921 | A | −0.14 (0.070) | 0.047 | 505 |
