Figure 5: Tmem176b single-deficient mouse susceptibility to the development of EAE, chronic and atute colitis. | Scientific Reports

Figure 5: Tmem176b single-deficient mouse susceptibility to the development of EAE, chronic and atute colitis.

From: RORγt+ cells selectively express redundant cation channels linked to the Golgi apparatus

Figure 5

(a) EAE was induced in WT (n = 6) and Tmem176b−/− (n = 8) mice by immunisation (s.c.) with MOG peptide in CFA. Clinical course of disease is shown. (b) Chronic colitis was induced in Rag1−/− mice (n = 11–12 in each group) by adoptive transfer (i.v.) of FACS-sorted CD4+CD45RBhi T cells from WT or Tmem176b−/− mice. Data are presented as percent of initial weight. (c) Acute colitis was induced in WT (n = 6) and Tmem176b−/− (n = 8) mice with 3% DSS in drinking water for 5 consecutive days. Data are presented as percent of initial weight.

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