Figure 2: SIRPα contributed to Foxo3a expression and apoptosis possibly by inhibiting β-catenin. | Scientific Reports

Figure 2: SIRPα contributed to Foxo3a expression and apoptosis possibly by inhibiting β-catenin.

From: Role of Signal Regulatory Protein α in Arsenic Trioxide-induced Promyelocytic Leukemia Cell Apoptosis

Figure 2

(a) Western blotting of p-Akt, Akt, p-GSK-3β, GSK-3β, β-catenin, Foxo3a and GAPDH in HL-60 and Huh7 cells infected with LV-SIRPα or LV-CTL on the third day post infection: representative Western blotting (left panels) and quantitative analysis (right panels). (b) Western blotting of β-catenin, Foxo3a, cleaved caspase-3 and GAPDH in LV-SIRPα-infected HL-60 cells co-incubated with 0, 5 and 10 μM LiCl or 0, 5, or 10 mM SB-216763. 48 hours post-infection of lentivirus, cells were treated with LiCl, or SB-216763 for 4 h and then lysed for Western blotting analysis: representative Western blot (left panels) and quantitative analysis (right panels). Values were shown as the mean ± SEM (n = 3). *P < 0.05. **P < 0.01.

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