Figure 4: Effects of smoking and host genetics on specific microbial taxa.
From: Analysis of the association between host genetics, smoking, and sputum microbiota in healthy humans
(a) Scatter plot of q-values for the association of each genus with pack-years of smoking (x-axis; from MaAsLin analysis) versus q-values for the heritability of each genus (y-axis; from SOLAR analysis). Red, blue, and green points represent genera that are significantly associated with pack-years of smoking, host genetics, and both, respectively. (b) Correlation network of the smoking (pack-years)- or host genetics-associated genera. Pink and light blue nodes indicate genera positively and negatively associated with smoking, respectively. Gray nodes indicate genera not significantly associated with smoking. The border of each node is colored according to the heritability (black: significant heritability with H2r > 0.3; gray: significant heritability with H2r < 0.3; white: non-significant heritability). Edges represent significant positive (dark gray) or negative (light gray) correlations between the nodes they connect. The width of the edge represents the degree of correlations.
