Figure 1

Dimerization of human UGT 1A1 and 1A9 alters their quercetin glucuronidation activities.

(A) Domains of UGT1A1*1/*1b and UGT1A9*1/*2/*3/*5; (B) Dimer detection by FRET using CFP and YFP tags; (C) Chemical reaction of quercetin glucuronidation catalyzed by UGT1A.