Figure 3
From: miR-93 functions as an oncomiR for the downregulation of PDCD4 in gastric carcinoma
Detection of an inverse correlation between miR-93 and PDCD4 levels in gastric cancer tissue samples.
(A) Schematic depicting the hypothetical duplexes formed through interactions between the binding sites in the PDCD4 3′-UTR (top) and miR-93 (bottom). The predicted free energy of each hybrid is indicated. The seed recognition sites are denoted and all nucleotides in these regions are highly conserved across species. (B) Quantitative RT-PCR analysis of the miR-93 expression levels in six pairs of GC and GN samples. (C) Pearson’s correlation scatter plot of the fold-change in the levels of miR-93 and PDCD4 protein in human gastric cancer tissues. (D) Pearson’s correlation scatter plot of the fold-change in the levels of miR-93 and PDCD4 mRNA in human gastric cancer tissues. ***P < 0.001.
