Figure 2
From: Substrate complexes of human dipeptidyl peptidase III reveal the mechanism of enzyme inhibition
Structures of opioid peptide complexes.
(a) Interactions of Met-enkephalin with hDPP III. The bound peptide is shown in cyan. Amino acid residues from the upper and lower lobe of hDPP III are shown in orange and grey, respectively. Dashed lines represent potential hydrogen bonding interactions. (b) Interactions with Leu-enkephalin (pink). (c) Interactions with endomorphin-2 (blue). (d) Interactions with the synthetic opioid peptide IVYPW (green). A magenta sphere represents the zinc ion in panels c and d. The figure was prepared using the program PyMol (http://www.pymol.org/).
