Figure 6: Effects of C5a and C5 on T-cell marker gene expression. | Scientific Reports

Figure 6: Effects of C5a and C5 on T-cell marker gene expression.

From: Connecting the innate and adaptive immune responses in mouse choroidal neovascularization via the anaphylatoxin C5a and γδT-cells

Figure 6

Splenic (B) and ocular (A) samples were isolated 6 days after induction of CNV and analyzed by QRT-PCR using primers specific for Th-17 (RORγ) and γδT-cells (γδTR). (A) Following CNV, mice treated with anti-C5 and anti-C5a demonstrated a significant decrease in ocular levels of IL-17 and γδTR gene expression, whereas RORγ levels were unaltered. (B). Splenic levels of T-cell-specific genes in CNV mice indicated that RORγ levels returned to control levels in mice treated with anti-C5 and anti-C5a, whereas γδTR remained significantly elevated (*P < 0.05). Data shown are average values (±SEM) (n = 3).

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