Figure 4: Western blot analysis of pramipexole-induced hypothermia on the apoptosis-related proteins and PI3K/AKT/GSK3β pathway in the brains of SAH rats. | Scientific Reports

Figure 4: Western blot analysis of pramipexole-induced hypothermia on the apoptosis-related proteins and PI3K/AKT/GSK3β pathway in the brains of SAH rats.

From: Pramipexole-Induced Hypothermia Reduces Early Brain Injury via PI3K/AKT/GSK3β pathway in Subarachnoid Hemorrhage rats

Figure 4

(A) Western blot analysis of the protein levels of Bcl-2, Bax and active-caspase-3 in brain tissues. (B) Statistical analysis of Bcl-2, Bax and caspase-3 activation in brain tissues. Data are expressed as means ± SEM. *p < 0.05, **p < 0.01 vs. sham group; #p < 0.05, ##p < 0.01 vs. SAH group, n = 6. (C) Western blot detection of phosphorylation of PI3K, AKT and GSK3β in brain tissues. (D) Statistical analysis of phosphorylation of PI3K, AKT and GSK3β in brain tissues. Phosphorylation levels were evaluated by the ratio of phosphoprotein to total protein. Data are expressed as means ± SEM. *p < 0.05 vs. sham group; #p < 0.05 vs. SAH group, n = 6. PPX: pramipexole.

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