Figure 5: In presence of pramipexole-induced hypothermia, effects of PI3K/AKT/GSK3β inhibitors on caspase-3 activation and albumin leakage in the brains of SAH rats. | Scientific Reports

Figure 5: In presence of pramipexole-induced hypothermia, effects of PI3K/AKT/GSK3β inhibitors on caspase-3 activation and albumin leakage in the brains of SAH rats.

From: Pramipexole-Induced Hypothermia Reduces Early Brain Injury via PI3K/AKT/GSK3β pathway in Subarachnoid Hemorrhage rats

Figure 5

(A) Western blot detection of LY294002, MK-2206 and CHIR99021 blockage of phosphorylation of PI3K, AKT and GSK3β. (C) Statistical analysis of PI3K, AKT and GSK3β phosphorylation in brain tissues. Data are expressed as means ± SEM. *p < 0.05 vs. SAH group; #p < 0.05, ##p < 0.01 vs. SAH + PPX group; n = 6. (B) Western blot detection of active caspase-3 and albumin in brain tissues. (D) Statistical analysis of activation of caspase-3 and albumin leakage in the brain tissues. Data are expressed as means ± SEM. *p < 0.05, **p < 0.01 vs. SAH group; #p < 0.05 vs. SAH + PPX group; n = 6. PPX: pramipexole.

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