Figure 8: Experimental Design. | Scientific Reports

Figure 8: Experimental Design.

From: Pramipexole-Induced Hypothermia Reduces Early Brain Injury via PI3K/AKT/GSK3β pathway in Subarachnoid Hemorrhage rats

Figure 8

(A,B) Schematic representation of the areas taken for assay. (A) Sham group. (B) Subarachnoid hemorrhage (SAH) group. (C) Design of dose-response experiment. (D) Experimental design for studying the effects of pramipexole-induced hypothermia and the possible mechanisms. Briefly, sixty-six rats (84 rats were used, 66 rats were survived) were randomly divided into 4 groups: normal group (n = 6), sham group (n = 12), SAH group (n = 12), and SAH + pramipexole group (n = 36). Among the 36 rats in SAH + pramipexole group, 24 rats were randomly subdivided into 4 groups: SAH + pramipexole + rewarming group (n = 6), SAH + pramipexole + LY294002 group (n = 6), SAH + pramipexole + MK-2206 group (n = 6), and SAH + pramipexole + CHIR99021 group (n = 6). PPX: pramipexole.

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