Table 2 Comparison studies which enrolled more than 100 CD patients.

From: Clinical spectrum and survival analysis of 145 cases of HIV-negative Castleman’s disease: renal function is an important prognostic factor

 

Dispenzieri A, et al.5

Dong Y, et al.6

Our study

Patient number

113

114

145

Median Age at CD diagnosis (years)

43

35

40

Male: Female

48 : 52

53.5 : 46.5

47.6 : 52.4

UCD: MCD

47 : 53

54.4 : 45.6

47.6 : 52.4

HV: PC: Mixed

47.8 : 47.8 : 4.4

59.6 : 26.3 : 14.1

51.0: 35.2 : 13.8

Paraneoplastic pemphigus (%)

1%

32.4%

4.8%

HIV status (positive cases/tested cases)

1/25

0/67

0/145

Years of patient enrollment

1948–2002

1977–2014

2000–2015

1–year Survival

Not mentioned

91.2%*

95.1%

2–year Survival

92.0%

Not mentioned

93.8%**

3–year Survival

Not mentioned

78.1%*

93.1%**

5–year Survival

76.0%

Not mentioned

91.0%

Risk factor for suvival***

Not mentioned

Paraneoplastic pemphigus

eGFR< 60 ml/min

  1. CD, Castleman’s disease; UCD, unicentric CD; MCD, multicentric CD; HV, hyaline-vascular variant; PC, plasma cell variant; eGFR, estimated glomerular filtration rate with Modification of Diet in Renal Disease (MDRD) equation. *estimated from published data; **calculated from our database (data not reported in manuscript); ***with multivariate Cox regression.
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