Figure 2
Human iPSC-derived neurons express functional ligand gated ion channels.
(a) Representative traces and histograms showing glutamate-evoked currents in human iPSC-derived neurons and the effects of CNQX and AP-5 on the currents. AMPAR: CNQX-sensitive currents, NMDAR: AP-5-sensitive currents. n = 8, P = 0.005 using one-way ANOVA (*P < 0.05 and **P < 0.01, compared with control). (b) GABA-evoked currents in human iPSC-derived neurons and the currents were blocked by bicuculline at 10 μM. n = 5, *P = 0.02. (c) Typical traces and histogram showing glycine-evoked currents in human iPSC-derived neurons and the effects of strychnine at 1 μM on the currents. n = 3, *P = 0.02.
