Table 3 The interactions between TN and PPT-type GS for thrombin inhibitory activity.
| 1.Ginsenoside-Rg1 | 2. Ginsenoside-Rh1 | ||||
|---|---|---|---|---|---|---|
Thrombin inhibition (%) at different combination ratios | Thrombin inhibition (%) at different combination ratios | |||||
1/4GS + 1TN | 1/2GS + 1TN | 1GS + 1TN | 1/4GS + 1TN | 1/2GS + 1TN | 1GS + 1TN | |
Dihydrotanshinone I | 46.80 ± 3.19 | 41.76 ± 3.93 | 30.43 ± 0.72 | 38.03 ± 0.88 | 35.60 ± 0.51 | 26.58 ± 2.59 |
Dose-dependent antagonism | Dose-dependent antagonism | |||||
Tanshinone I | 60.91 ± 0.63 | 51.25 ± 0.00 | 25.50 ± 12.68 | 51.19 ± 0.68 | 35.07 ± 8.73 | 25.12 ± 0.66 |
Dose-dependent antagonism | Dose-dependent antagonism | |||||
Cryptotanshinone | 43.70 ± 1.28 | 33.70 ± 4.29 | 26.81 ± 2.70 | 61.3 ± 3.17 | 60.38 ± 2.52 | 7.54 ± 1.41 |
Dose-dependent antagonism | Dose-dependent antagonism | |||||
Tanshinone IIA | 52.89 ± 0.74 | 47.28 ± 0.36 | 19.14 ± 1.79 | 34.12 ± 2.57 | 23.06 ± 1.36 | 17.57 ± 0.36 |
Dose-dependent antagonism | Dose-dependent antagonism | |||||
