Table 4 The interactions between TN and PPD-type GS for thrombin inhibitory activity.

From: A chemical family-based strategy for uncovering hidden bioactive molecules and multicomponent interactions in herbal medicines

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1. Ginsenoside-Rb1

2. Ginsenoside-Rd

Thrombin inhibition (%) at different combination ratios

Thrombin inhibition (%) at different combination ratios

1/4GS + 1TN

1/2GS + 1TN

1GS + 1TN

1/4GS + 1TN

1/2GS + 1TN

1GS + 1TN

Dihydrotanshinone I

44.30 ± 2.01

39.47 ± 3.72

9.87 ± 2.79

38.72 ± 1.92

27.61 ± 1.41

2.68 ± 2.37

Counteraction a

Counteraction

Tanshinone I

31.05 ± 8.19

30.19 ± 9.19

4.83 ± 4.83

71.20 ± 0.00

5.20 ± 3.39

2.20 ± 2.55

Counteraction

Counteraction

Cryptotanshinone

24.88 ± 0.86

−10.24 ± 2.41

−16.75 ± 3.44

8.82 ± 2.79

−5.31 ± 2.55

−7.65 ± 4.10

Reverse b

Reverse

Tanshinone IIA

34.02 ± 1.86

2.05 ± 0.32

−9.74 ± 0.48

69.17 ± 3.74

−2.09 ± 3.34

−4.10 ± 1.18

Reverse

Reverse

  1. aThe thrombin inhibition ranged from 0% to 10% when the combination ratio of GS and TN was 1:1(1GS + 1TN).
  2. bThe thrombin inhibition was negative when the combination ratio of GS and TN was 1:1(1GS + 1TN).
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