Figure 5
From: Molecular Interactions between Tarantula Toxins and Low-Voltage-Activated Calcium Channels
Comparison of related toxins on Cav3.1 inhibition and membrane partitioning strength.
(a) Cav3.1 inhibition vs. strength of membrane partitioning. (b) ProTx-II, PaTx-1, GsAF-I and GsAF-II structures superimposed based on their backbone fold. Side chains of residues within sites 1–3 are colored red (acidic), green (hydrophobic), purple (serine) and yellow (glycine and alanine). (c) Toxin surface profiles, colored based on the normalized Eisenberg hydrophobicity scale64. The most hydrophobic residues are in red, following a color gradient to the most hydrophilic residues in white.
