Figure 1 | Scientific Reports

Figure 1

From: Vancomycin-sensitive bacteria trigger development of colitis-associated colon cancer by attracting neutrophils

Figure 1

Vancomycin reduced the risk of colitis-associated carcinogenesis.

(A) Schematic of mice treated with AOM/DSS. After initial AOM injection (12 mg/kg), DSS was given in drinking water followed by regular water three times. Antibiotics (combination of vancomycin and neomycin, vancomycin alone, or neomycin alone) were administered throughout this procedure. (B) Macroscopic view of tumor formation in colon-rectum regions of AOM/DSS-treated control mice and antibiotics (vancomycin/neomycin, vancomycin, or neomycin) -treated mice at day 67. (C) Statistical analysis of tumor number in colon-rectum regions at day 67. Data represent mean ± SEM (−, n = 8; V/N, n = 7; V, n = 8; N, n = 5). **p < 0.01, ***p < 0.001. (D) H&E staining of distal colon at day 67. Scale bar: 100 μm. ABX, antibiotics; AOM, azoxymethane; DSS, dextran sodium sulfate; H&E, hematoxylin and eosin; i.p., intraperitoneal; N, neomycin; n.s., not significant; SEM, standard error of the mean; V, vancomycin; V/N, vancomycin and neomycin.

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