Figure 5 | Scientific Reports

Figure 5

From: Vancomycin-sensitive bacteria trigger development of colitis-associated colon cancer by attracting neutrophils

Figure 5

Vancomycin reduced DNA damage in colon epithelial cells through downregulating pro-inflammatory mediator expression.

(A) Real-time PCR analysis of distal colon at day 10. (B) ROS production from lamina propria-infiltrated cells at day 10. (C) Immunohistochemical analysis of distal colon at day 10. The DNA damage marker p-H2AX is shown. Scale bar: 50 μm. (D) Statistical analysis of p-H2AX positive cells in each field (×400). AOM, azoxymethane; DSS, dextran sodium sulfate; N, neomycin; ROS, reactive oxygen species; SEM, standard error of the mean; V, vancomycin; V/N, vancomycin and neomycin. Data represent mean ± SEM (n = 6). *p < 0.05, **p < 0.01, ***p < 0.001.

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