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Figure 2

From: Two mutations G335D and Q343R within the amyloidogenic core region of TDP-43 influence its aggregation and inclusion formation

Figure 2

Aggregation of TDP(311–360) and its mutants in vitro.

(a) Time courses showing aggregation of the Trx fusions of TDP(311–360) and its mutants upon thrombin cleavage. The aggregation ability was represented by ThT fluorescence intensity. The protein concentration was 100 μM. Trx, thioredoxin. (b) Time courses showing aggregation of the purified TDP(311–360) and its mutants. The peptide concentration was 100 μM. Shown are three independent experiments (n = 3).

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