Figure 3 | Scientific Reports

Figure 3

From: Two mutations G335D and Q343R within the amyloidogenic core region of TDP-43 influence its aggregation and inclusion formation

Figure 3

NMR solution structures of the G335D and Q343R mutants of TDP(311–360) peptide.

(a) Ensemble of the 10 lowest-energy structures of G335D superimposed on backbones of the first helix (left) or the second helix (right), respectively. (b) Ribbon diagram of a representative structure of G335D showing a helix-loop-helix structure. (c) Superposition of the backbone traces of the 10 lowest-energy structures of Q343R. (d) Ribbon representation of the backbone structure of Q343R showing a helix and a flexible tail. (e) Overlay of the structures of TDP(311–360) (purple), G335D (yellow) and Q343R (cyan). The N-terminal α-helix was selected to overlap. N, N terminus; C, C terminus. The structures are displayed with MOLMOL.

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