Figure 4 | Scientific Reports

Figure 4

From: Two mutations G335D and Q343R within the amyloidogenic core region of TDP-43 influence its aggregation and inclusion formation

Figure 4

Structural transformation and aggregation of the TDP(311–360) mutants.

(a,c,e) Time courses of the CD spectrum changes of M337V (a), G335D (c) and Q343R (e) in solution during incubation processes. For time-course incubation, the concentration of each protein was 100 μM in a buffer (100 mM phosphate, 100 mM NaCl, pH7.0). (b, d) Secondary-structure content changes of M337V (b) and G335D (d) at various incubation times. The data were obtained from analyzing the CD spectra (a,c) with a computer program. (f) Comparison of the solid-state CD spectra of TDP(311–360) and its mutants.

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