Table 1 PFOA concentration, body masses and organ indexes after 28 d exposure to PFOA.

From: Effects of Perfluorooctanoic Acid on Metabolic Profiles in Brain and Liver of Mouse Revealed by a High-throughput Targeted Metabolomics Approach

Group

Control

Low

High

Dose of PFOA (mg/kg/day)

0

0.5

2.5

PFOA in blood (μg/mL)

0.011(0.0057)

29.34(5.06)**

114.3(21.80)**

PFOA in brain (μg/g)

0.011(0.0051)

0.26(0.062)**

0.92(0.12)**

PFOA in liver (μg/g)

0.026(0.021)

29.50(6.44)**

166.9(63.83)**

Body(g)

21.08(1.44)

20.58(2.39)

20.70(1.07)

Liver(g)

1.08(0.13)

1.14(0.17)

1.37(0.21)*

Liver/Body(%)

5.10(0.41)

5.52(0.27)

6.62(0.66)**

Brain(g)

0.52(0.05)

0.52(0.07)

0.43(0.07)

Brain/Body(%)

2.49(0.28)

2.53(0.38)

2.06(0.32)

  1. Data are mean (standard deviation).
  2. *P < 0.05, **P < 0.01 versus their corresponding controls, using one-way ANOVA with Tukey post hoc comparison.
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