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Figure 1

From: Quercetin Inhibits Fibroblast Activation and Kidney Fibrosis Involving the Suppression of Mammalian Target of Rapamycin and β-catenin Signaling

Figure 1

Quercetin ameliorates UUO nephropathy in mice.

Male CD-1 mice received UUO operation were treated with quercetin (25 mg/kg.day) and sacrificed at 2 weeks after surgery. (A) Representative micrographs for periodic acid–Schiff (PAS), Masson and Sirius red staining in the kidneys from different groups as indicated. Scale bar = 50 μm. (B) Graphic presentation showing the percentage of fibrotic area in the kidneys from different groups as indicated. *P < 0.05 compared with Sham kidneys (n = 3–7); #P < 0.05 compared with UUO kidneys with vehicle treatment (n = 7). (C) Graphic presentation showing total collagen content in the kidneys from different groups as indicated. *P < 0.05 compared with Sham kidneys (n = 3–7); #P < 0.05 compared with UUO kidneys with vehicle treatment (n = 7).

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