Figure 1: Metformin protects against cisplatin-induced AKI. | Scientific Reports

Figure 1: Metformin protects against cisplatin-induced AKI.

From: Metformin Protects Against Cisplatin-Induced Tubular Cell Apoptosis and Acute Kidney Injury via AMPKα-regulated Autophagy Induction

Figure 1

The male CD1 mice were treated with vehicle or metformin (100 or 200 mg/kg per day, ip) for 3 days, followed by cisplatin injection (20 mg/kg, ip), and sacrificed at day 2 after cisplatin injection. (A) The graph showing the blood urea nitrogen (BUN) levels in each group. *P < 0.05 compared to vehicle control (n = 6 − 18); #P < 0.05 compared to mice treated with cisplatin alone (n = 6 − 18). (B) Periodic acid-Schiff (PAS) staining showing the histological changes within groups. The asterisks indicate the injured tubule. Bar = 50 μm. (C) The graph showing the injury scores for kidney damage within groups. *P < 0.05 compared to vehicle control (n = 3 − 5); #P < 0.05 compared to mice treated with cisplatin alone (n = 5).

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