Figure 2: Metformin reduces tubular cell apoptosis in the kidneys with cisplatin-induced AKI. | Scientific Reports

Figure 2: Metformin reduces tubular cell apoptosis in the kidneys with cisplatin-induced AKI.

From: Metformin Protects Against Cisplatin-Induced Tubular Cell Apoptosis and Acute Kidney Injury via AMPKα-regulated Autophagy Induction

Figure 2

(A) Representative micrographs showing the TUNEL staining and immnuo-staining images for cleaved caspase 3 among different groups. Bar = 50 μm. (B) Quantitative analysis for the number of TUNEL staining positive cells among different groups. *P < 0.05 compared to vehicle control, (n = 3 − 5); #P < 0.05 compared to mice treated with cisplatin alone (n = 5). (C) Quantitative determination for the number of cleaved caspase 3 positive cells among different groups. *P < 0.05 compared to vehicle control (n = 3 − 5); #P < 0.05 compared to mice treated with cisplatin alone (n = 5).

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